Research Article
Exercise Reduces Morphine-Induced Hyperalgesia and Antinociceptive Tolerance
Figure 2
IT injection of SB203580 10 μg prevented morphine tolerance in the (a) hot-plate test and (b) tail-flick test. Morphine 30 mg/kg was injected daily, and behavior tests were performed 30 minutes after morphine subcutaneous injection. On 7th day, SB203580 10 μg was IT injected before behavior tests. “a” denotes the statistically significant difference compared to the saline group, and “b” denotes the statistically significant difference compared to the saline+morphine group.
| (a) |
| (b) |