Combination Therapy of Chemoembolization and Hepatic Arterial Infusion Chemotherapy in Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis Compared with Chemoembolization Alone: A Propensity Score-Matched Analysis
Table 5
Treatment-related adverse events in the groups (matched).
cTACE group ()
cTACE+HAIC group ()
value
Any grade 3-4
13 (21.7)
14 (23.3)
0.827
Blood suppression
Leukopenia
Grades 1 to 2
6 (10.0)
6 (10.0)
1.000
Grades 3 to 4
0 (0.0)
0 (0.0)
1.000
Neutropenia
Grades 1 to 2
2 (3.3)
3 (5.0)
0.5
Grades 3 to 4
0 (0.0)
0 (0.0)
1.000
Reduced hemoglobin
Grades 1 to 2
12 (20.0)
14 (23.3)
0.658
Grades 3 to 4
1 (1.6)
2 (3.3)
0.500
Thrombocytopenia
Grades 1 to 2
17 (28.3)
26 (43.3)
0.087
Grades 3 to 4
2 (3.3)
2 (3.3)
1.000
Constitutional symptom
Fever
Grades 1 to 2
43 (71.7)
41 (68.3)
0.690
Grades 3 to 4
3 (5.0)
0 (0.0)
0.244
Indigestion
Vomiting
Grades 1 to 2
13 (21.7)
25 (41.7)
0.019
Grades 3 to 4
0 (0)
0 (0.0)
1.000
Hepatic function
Elevated ALT
Grades 1 to 2
49 (81.7)
36 (60.0)
0.009
Grades 3 to 4
5 (8.3)
7 (11.7)
0.543
Elevated AST
Grades 1 to 2
50 (83.3)
44 (73.3)
0.184
Grades 3 to 4
6 (10.0)
7 (11.7)
0.769
Elevated TBIL
Grades 1 to 2
41 (68.3)
46 (76.7)
0.307
Grades 3 to 4
9 (15.0)
3 (5.0)
0.068
Hypertension
Grades 1 to 2
9 (15.0)
12 (20.0)
0.471
Grades 3 to 4
0 (0.0)
0 (0.0)
1.000
Pain
Grades 1 to 2
40 (66.7)
42 (70.0)
0.695
Grades 3 to 4
0 (0)
0 (0.0)
1.000
TACE: transcatheter arterial chemoembolization; HAIC: hepatic arterial infusion chemotherapy; ALT: alanine aminotransferase; AST: aspartate aminotransferase; TBIL: total bilirubin. Statistical significance was assessed with the test or Fisher’s exact test.
