A Bioinformatic Investigation of the Mechanism Underlying Migraine-Induced Erectile Dysfunction

Figure 1

Study flowchart. We predicted the proteins and pathways associated with migraine and erectile dysfunction. We used RT-qPCR and western blotting to measure expression of proteins and mRNA in rat penis cells of each group. The results of in vivo experiments were consistent with the prediction results of bioinformatic analysis. The decline of erectile function in a rat model of migraine was associated with the PI3K/Akt/mTOR signaling pathway.