Single Immunoglobulin IL-1-Related Receptor (SIGIRR) Gene rs7396562 Polymorphism and Expression Level in Rheumatoid Arthritis

Table 2

Allele and genotype frequencies of SIGIRR rs7396562 polymorphism in RA patients and controls.

SNPs	Genotype	RA (), (%)	Controls (), (%)	OR (95% CI)	value
rs7396562	TT	196 (37.9)	179 (29.8)	1.547 (1.107-2.163)	0.011
	TG	229 (44.3)	292 (48.6)	1.108 (0.806-1.523)	0.527
	GG	92 (17.8)	130 (21.6)	Reference
	T	621 (60.1)	650 (54.1)	1.277 (1.079-1.511)	0.004
	G	413 (39.9)	552 (45.9)	Reference
Dominant model	TT+TG	425 (82.2)	471 (78.4)	1.275 (0.947-1.717)	0.109
	GG	92 (17.8)	130 (21.6)	Reference
Recessive model	TT	196 (37.9)	179 (29.8)	1.439 (1.122-1.847)	0.004
	TG+GG	321 (62.1)	422 (70.2)	Reference

RA: rheumatoid arthritis; OR: odds ratio; CI: confidence interval; NA: not available. Statistically significant ().