Research Article
Canine Natural Killer Cell-Derived Exosomes Exhibit Antitumor Activity in a Mouse Model of Canine Mammary Tumor
Figure 5
Effects of canine NK-exosomes on the expression of cancer stem cell markers. (a, b) To examine whether activated NK-exosomes influence the expression of CSC-related markers (CD133, Bmi-1, VEGF, MMP-3, IL-1β, IL-6, TNF-α, MDR, Bax, Bcl-xL, p53, and PCNA), the expression level of tumorigenesis-related marker was examined in control, untreated tumor, and NK-exosome-treated tumor groups. , , . (c) We monitored the tumor volume of the mice in the tumor group (REM134, top) and NK-exosome-treated tumor group (REM134/NK-exosomes, bottom) in the REM134-driven tumorigenic mouse model. Representative images are shown (2, 4, 6, and 8 weeks after tumor induction).
(a) |
(b) |
(c) |