Serum Glycocholic Acid-to-Total Bile Acid Ratio Is Independently Associated with Nonalcoholic Fatty Liver Disease: A Retrospective Cross-Sectional Study
Table 2
Basic characteristics of the study population categorized by quartiles of the GCA-to-TBA ratio.
Parameters
Q1 ()
Q2 ()
Q3 ()
Q4 ()
Clinical characteristics
Age (years)
46 (37-55)
45 (36-54)
43 (36-52)
44 (36-53)
Gender, male
1186 (70.7)
1123 (66.7)
1036 (61.3)
921 (55.6)
BMI (kg/m2)
24.8 (22.6-27.1)
24.6 (22.4-26.8)
24.1 (22.1-26.5)
24.1 (22.0-26.6)
NAFLD (%)
815 (48.6)
757 (45.0)
646 (38.2)
641 (38.7)
Diabetes (%)
116 (6.9)
94 (5.6)
76 (4.5)
61 (3.7)
Metabolic syndrome (%)
282 (16.8)
244 (14.5)
232 (13.7)
200 (12.1)
Hypertension (%)
525 (31.3)
445 (26.4)
421 (24.9)
373 (22.5)
Biochemical data
ALT (IU/L)
23 (16-35)
22 (15-34)
20 (14-30)
19 (14-28)
AST (IU/L)
23 (19-28)
22 (19-27)
21 (18-26)
21 (18-25)
ALP (IU/L)
75 (62-89)
73 (61-86)
71 (59-85)
70 (59-85)
γ-GT (IU/L)
27 (17-44)
25 (16-42)
22 (15-36)
21 (15-34)
BUN (mmol/L)
5.0 (4.3-5.9)
5.1 (4.3-6.0)
5.0 (4.3-5.8)
4.9 (4.2-5.7)
Creatinine (μmol/L)
80 (71-88)
80 (68-88)
78 (68-88)
78 (66-88)
Uric acid (μmol/L)
359 (299-425)
358 (292-422)
348 (285-411)
340 (279-406)
FBG (mmol/L)
5.10 (4.76-5.50)
5.04 (4.75-5.46)
5.05 (4.73-5.40)
5.01 (4.73-5.38)
Triglyceride (mmol/L)
1.48 (1.02-2.23)
1.37 (0.94-2.09)
1.27 (0.88-1.88)
1.25 (0.89-1.79)
Total cholesterol (mmol/L)
4.98 (4.41-5.68)
5.04 (4.38-5.67)
5.00 (4.39-5.64)
4.96 (4.37-5.60)
0.312
HDL-C (mmol/L)
1.17 (1.02-1.36)
1.20 (1.05-1.41)
1.22 (1.06-1.43)
1.23 (1.06-1.42)
LDL-C (mmol/L)
3.24 (2.80-3.74)
3.25 (2.75-3.77)
3.23 (2.76-3.73)
3.21 (2.74-3.70)
0.225
Data are shown as the median and interquartile range (IQR) or percentages. values were from analysis of the Kruskal-Wallis test or Pearson’s test. A two-tailed value of less than 0.05 was considered statistically significant. NAFLD: nonalcoholic fatty liver disease; BMI: body mass index; ALT: alanine aminotransferase; AST: aspartate aminotransferase; ALP: alkaline phosphatase; γ-GT: γ-glutamyl transpeptidase; TBA: total bile acids; GCA: glycocholic acid; BUN: blood urea nitrogen; FBG: fasting blood glucose; LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol; Q1: the GCA-to-TBA ; Q2: the GCA-to-TBA ratio 0.75-1.00; Q3: the GCA-to-TBA ratio 1.00-1.34; Q4: the GCA-to-TBA .
