Research Article
Downregulation of snoRNA SNORA52 and Its Clinical Significance in Hepatocellular Carcinoma
Table 1
Correlation of SNORA52 and clinical characteristics in HCC patients.
| Characteristics | Total | SNORA52 expression | value | Low () | High () |
| Age (ys) | | | | 0.607 | <60 | 92 | 44 (0.611) | 48 (0.658) | | ≥60 | 53 | 28 (0.389) | 25 (0.342) | | Gender | | | | 0.138 | Female | 19 | 6 (0.083) | 13 (0.178) | | Male | 126 | 66 (0.917) | 60 (0.822) | | Hepatitis B | | | | 0.810 | Positive | 125 | 63 (0.875) | 62 (0.849) | | Negative | 20 | 9 (0.125) | 11 (0.151) | | Cirrhosis | | | | 1.000 | Present | 89 | 44 (0.611) | 45 (0.616) | | Absent | 56 | 28 (0.389) | 28 (0.384) | | AFP (ng/l) | | | | 0.230 | <400 | 92 | 42 (0.583) | 50 (0.685) | | ≥400 | 53 | 30 (0.417) | 23 (0.315) | | Tumor diameter | | | | 0.011 | <5 cm | 43 | 14 (0.194) | 29 (0.397) | | ≥5 cm | 102 | 58 (0.806) | 44 (0.603) | | Multiple lesions | | | | 0.007 | Absent | 24 | 18 (0.250) | 6 (0.082) | | Present | 121 | 54 (0.750) | 67 (0.918) | | Vessel carcinoma embolus | | | | 0.127 | Absent | 109 | 50 (0.694) | 59 (0.808) | | Present | 36 | 22 (0.306) | 14 (0.192) | | Microvascular invasion | | | | 1.000 | Absent | 136 | 68 (0.944) | 68 (0.932) | | Present | 9 | 4 (0.056) | 5 (0.068) | | Capsular invasion | | | | 0.011 | Absent | 88 | 36 (0.500) | 52 (0.712) | | Present | 57 | 36 (0.500) | 21 (0.288) | | Differentiation | | | | 0.046 | Low | 76 | 44 (0.377) | 32 (0.438) | | High/moderate | 69 | 28 (0.389) | 41 (0.562) | | TNM stage | | | | 0.004 | I~II | 101 | 42 (0.583) | 59 (0.808) | | III~IV | 44 | 30 (0.417) | 14 (0.192) | |
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AFP: α-fetoprotein; TNM: tumor-node-metastasis; . Values are presented as the or (%). |