[Retracted] Upregulation of miR-29c-3p Hinders Melanoma Progression by Inhibiting CDCA4 Expression

Figure 4

Effects of CDCA4 on biological functions of MM cells and EMT-related proteins. (a) CDCA4 is highly expressed in MM cells, especially in M21 and C8161 cells. (b) Expression of CDCA4 is suppressed markedly in cells transfected with si-CDCA4. (c) Proliferation of cells transfected with si-CDCA4 is hindered markedly. (d) Migration of cells transfected with si-CDCA4 is hindered markedly. (e) Invasion of cells transfected with si-CDCA4 is hindered markedly. (f) Expression of Bcl-2 protein in cells transfected with si-CDCA4 is remarkably suppressed, while those of Bax and Caspase3 proteins are remarkably elevated. Apoptosis of cells transfected with si-CDCA4 is significantly enhanced. The protein map and flow cytometry diagram are provided. (g) Expression of N-cadherin and vimentin proteins in the cells transfected with si-CDCA4 is remarkably suppressed, while that of E-cadherin protein is remarkably elevated. The protein map is provided. Note: , vs. the miR-NC group or HFF cells; ^# vs. the miR-29c-3p-inhibitor group.

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