Targeting Endothelin in Alzheimer’s Disease: A Promising Therapeutic Approach

Figure 1

Endothelin precursor gene present in the human brain by transcription and translation processes leads to the formation of endothelin, and its rise causes an increase in vascular cell adhesion protein (VCAM), cell adhesion protein (CAM), selectin, white matter ischemia, decrease in the ratio of myeline-associated protein and proteolipid protein increasing various factors like free radical formation, inflammation, cell coagulation, cell proliferation, decrease glucose level, and blood flow directing towards the pathogenesis of Alzheimer disease.