Expression of Circulating MicroRNAs and Myokines and Interactions with Serum Osteopontin in Type 2 Diabetic Patients with Moderate and Poor Glycemic Control: A Biochemical and Molecular Study

Figure 3

MicroRNAs’ differential expression profile in moderate glycemic controlled T2D (MCT2D; >7-8% HbA1c, ) and poor glycemic controlled T2D (PCT2D; >8% HbA1c, ) (a). The results showed that the relative expression of miR-146a significantly decreased () and miR-144 significantly increased () in poor glycemic controlled T2D patients compared to moderate glycemic controlled T2D. In addition, female patients showed more significant change in the expression levels of miR-146a (b) and miR-144 (c) compared to that of male subjects of the same group. Significance at ^a (male vs. female); ^b (moderately controlled vs. poorly controlled type 2 diabetes).

(a)

(b)

(c)