Expression of Circulating MicroRNAs and Myokines and Interactions with Serum Osteopontin in Type 2 Diabetic Patients with Moderate and Poor Glycemic Control: A Biochemical and Molecular Study

Table 3

Correlations of osteopontin (OPN) with inflammatory cytokines and clinical parameters of diabetes with different controls.

Studied parameters	OPN ()
	Moderate glycemic controlled (>7-8% HbA1c, )	Poor glycemic controlled (>8% HbA1c, )
HbA1c (%)	0.58^a	0.68^b
FINS (mUI/mL)	0.46^a	0.72^b
HOMA-IR	0.41^a	0.46^b
CRP (mg/L)	0.62^a	0.78^b
TNF-α (pg/mL)	0.43^a	0.74^b
IL-6 (pg/mL)	0.48^a	0.59^b
IL-8 (pg/mL)	0.68^a	0.74^b
IL-18 (pg/mL)	0.56^a	0.58^b
IL-1β (pg/mL)	0.46^a	0.49^b
Interpretation of the correlation coefficient ()	Moderate	Moderate-strong

Data are presented as Pearson’s () coefficients adjusting for variables identified as cofounders in univariate analyses. Moderate correlation coefficient (0.40-0.69); strong correlation coefficient (0.70-0.89). Significance at . ^a; ^b. HbA1c: glycated hemoglobin A1c.