Expression of Circulating MicroRNAs and Myokines and Interactions with Serum Osteopontin in Type 2 Diabetic Patients with Moderate and Poor Glycemic Control: A Biochemical and Molecular Study

Table 4

Correlations of adropin and irisin with clinical and laboratory parameters of diabetic patients with different controls.

Studied parameters	Myokines ()
	Moderate glycemic controlled T2D (MCT2D; >7-8% HbA1c, )		Poor glycemic controlled T2D (PCT2D; >8% HbA1c, )
	Adropin	Irisin	Adropin	Irisin
BMI	-0.46^b	-0.54^b	-0.48^b	-0.54^b
HbA1c (%)	0.41^b	0.43^b	0.45^b	0.43^b
FINS (mUI/mL)	0.56^b	0.48^b	0.66^b	0.48^b
HOMA-IR	0.48^b	0.53^b	0.51^b	0.53^b
OPN	-0.45^b	-0.65^b	-0.55^b	-0.65^b
CRP (mg/L)	-0.44^b	-0.41^b	-0.46^b	-0.41^b
TNF-α (pg/mL)	-0.67^a	-0.65^b	-0.83^a	-0.85^b
IL-6 (pg/mL)	-0.46^a	-0.63^b	-0.63^a	-0.63^b
IL-8 (pg/mL)	-0.63^b	-0.68^b	-0.68^b	-0.78^b
IL-18 (pg/mL)	-0.42^a	-0.45^b	-0.52^a	-0.45^b
IL-1β (pg/mL)	-0.61^a	-0.64^a	-0.81^a	-0.64^a
Interpretation of the correlation coefficient ()	Moderate	Moderate	Moderate-strong	Moderate-strong

Data are presented as Pearson’s () coefficients adjusting for variables identified as cofounders in univariate analyses. Moderate correlation coefficient (0.40-0.69); strong correlation coefficient (0.70-0.89). Significance at . ^a; ^b. HbA1c: glycated hemoglobin A1c.