Expression of Circulating MicroRNAs and Myokines and Interactions with Serum Osteopontin in Type 2 Diabetic Patients with Moderate and Poor Glycemic Control: A Biochemical and Molecular Study

Table 5

Correlations of miRNAs, miR-146a and miR-144, with clinical and laboratory parameters of diabetic patients with different controls.

Studied parameters	miRNA expression
	Moderate glycemic controlled T2D (MCT2D; >7-8% HbA1c, )		Poor glycemic controlled T2D (PCT2D; >8% HbA1c, )
	miR-146a	miR-144	miR-146a	miR-144
HbA1c (%)	-0.41^b	0.46^b	-0.46^b	0.52^b
FINS (mUI/mL)	-0.46^b	0.53^b	-0.42^b	0.58^b
HOMA-IR	-0.58^b	0.48^b	-0.53^b	0.51^b
OPN	-0.57^b	0.49^b	-0.55^b	0.79^b
CRP (mg/L)	-0.46^b	-0.52^b	-0.47^b	-0.54^b
TNF-α (pg/mL)	-0.54^a	-0.85^b	-0.59^a	-0.87^b
IL-6 (pg/mL)	-0.58^a	-0.42^b	-0.61^a	-0.48^b
IL-8 (pg/mL)	-0.42^b	-0.54^b	-0.46^b	-0.56^b
IL-18 (pg/mL)	-0.68^a	-0.53^b	-0.71^a	-0.58^b
IL-1β (pg/mL)	-0.50^a	-0.56^a	-0.58^a	-0.61^a
Adropin (ng/mL)	0.65^a	0.51^a	0.78^a	0.75^a
Irisin (ng/mL)	0.61^a	0.52^a	0.71^a	0.82^a
Interpretation of the correlation coefficient ()	Moderate	Moderate	Moderate-strong	Moderate-strong

Data are presented as Pearson’s () coefficients adjusting for variables identified as cofounders in univariate analyses. Moderate correlation coefficient (0.40-0.69); strong correlation coefficient (0.70-0.89). Significance at . ^a; ^b. HbA1c: glycated hemoglobin A1c; OPN: osteopontin; CRP: C-reactive protein; TNF-α: tumor necrosis factor-α. Interleukins (IL-6, IL-8, IL-18, and IL-1β).