Retinal Degeneration in a Murine Model of Retinal Ischemia by Unilateral Common Carotid Artery Occlusion

Figure 1

General characteristics of a murine model of retinal ischemia induced by unilateral common carotid artery occlusion (UCCAO). (a) A schematic illustration of the surgical procedure for UCCAO. UCCAO was performed by permanent suturing of the right common carotid artery (CCA). ICA: internal carotid artery; ECA: external carotid artery. Gray box, the cutting area. (b) Representative images of permanent eyelid drooping after UCCAO. (c) There was no significant change in axial length on week 2 (W2) and week 4 (W4) after UCCAO ( per group). . (d) A representative image of acute reversible cataract under medetomidine, midazolam, and butorphanol- (MMB-) induced anesthesia. The induction time point of acute reversible cataract in UCCAO-operated mice was shorter than that in sham-operated mice under MMB-induced anesthesia with-and-without pupil dilation ( per group). and . (e) Representative images of pupillary light reflex (PLR). The gross observation indicated that PLR was normal in UCCAO-operated mice under the dark/light condition, similar with that in sham-operated mice ( per group). (f) There was no significant change in intraocular pressure (IOP) on day 0 (D0, right after UCCAO), week 2 (W2), and week 4 (W4) after UCCAO ( per group). . The data were analyzed using Student’s -test (two-tailed) and presented as .

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