Retinal Degeneration in a Murine Model of Retinal Ischemia by Unilateral Common Carotid Artery Occlusion

Figure 5

Visual dysfunction and ganglion cell loss after UCCAO. (a, b) Representative waveforms of visual evoked potential (VEP) responsive to a stimulus intensity of 3 cd.s/m². The amplitude of VEP in the UCCAO-operated eyes significantly decreased compared to that in the sham-operated eyes on week 2 (W2) and week 4 (W4) after UCCAO (3 cd.s/m²) ( per group). . (c) Representative images and quantitative analyses showed that the number of NeuN-positive cells in GCL of UCCAO-operated mice significantly decreased compared with that in GCL of sham-operated mice 2 weeks after UCCAO ( per group). . GCL: ganglion cell layer; INL: inner nuclear layer; ONL: outer nuclear layer. White dotted squares, enlarged images. Scale bar, 100 and 50 (enlarged) μm. (d) Representative images and quantitative analyses showed there was no significant change in the RPE/choroidal thickness on week 2 (W2) and week 4 (W4) after UCCAO ( per group). . Scale bar, 200 μm. The data were analyzed using Student’s -test (two-tailed) and presented as .

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