MAPK and Notch-Mediated Effects of Meso-Xanthin F199 Compounds on Proliferative Activity and Apoptosis of Human Melanocytes in Three-Dimensional Culture

Figure 1

Morphology of melanocytes in 2D and 3D cell cultures. In passage 4, the culture of human melanocytes was represented by cells with spindle-shaped or dendritic cells (a). Cells in nonadhesive microwells formed dark compact spheroids both in control growth medium (b) and in the presence of Meso-Xanthin F199™ (c). Light phase-contrast microscopy.

(a)

(b)

(c)