MAPK and Notch-Mediated Effects of Meso-Xanthin F199 Compounds on Proliferative Activity and Apoptosis of Human Melanocytes in Three-Dimensional Culture

Figure 2

Descriptive primary analysis of the obtained proteomes among studied melanocyte cells cultivated in a monolayer and in spheroids before and after exposure to FX (a). Protein distribution among studied human melanocyte cultures. The total size of the significantly contributing proteome was 434 protein identifications, which is about 19% of the individual proteome of each sample. (b) Distribution of the symmetry coefficient dependent on the cumulative number of protein identifications. The maximum increase in the symmetry coefficient is observed with the accumulation of 80%-87% of the summarized size of the proteome. Most of the identified proteins among studied melanocyte samples make an insignificant contribution to the growth of the asymmetry of the distribution (up to 0.0025 units per protein).

(a)

(b)