MAPK and Notch-Mediated Effects of Meso-Xanthin F199 Compounds on Proliferative Activity and Apoptosis of Human Melanocytes in Three-Dimensional Culture

Figure 4

Network interaction analysis of proteins with positive regulation in cells before (Nm01) and after (Am02) exposure to Meso-Xanthin F199. The resulting network establishes interactions in the streamlining processes of cell response to stimulation and activation of RNA metabolism. The background biological processes actively undergoing after exposure to Meso-Xanthin are a response to stimulation (GO: 0051716, ), which reflects changing the state and activity of the cell (including gene expression, secretion, and enzymatic activity) and the closely related process of signal transmission (GO: 0007165, ). In general, these biological processes agree well with those molecular functions that have been identified in this study (protein binding and protein metabolism and RNA binding and metabolism). In addition, groups of proteins with phosphatase and GTPase activity (GO: 0003924, ), which are upstream to protein metabolism actively involved in translation and assembly of ribonucleoproteins, were also identified in this network.