MAPK and Notch-Mediated Effects of Meso-Xanthin F199 Compounds on Proliferative Activity and Apoptosis of Human Melanocytes in Three-Dimensional Culture

Figure 5

Dynamic alterations of Rap1- and MAPK4/MAPK6-related proteins overlapped between analyzed melanocytes. Proteins regulating the activity of MAPK4 and MAPK6 kinases (PRS6A, PRS6B, PRS7, and PSMD2) are characterized by the maximum abundancy in the Am02 culture (after exposure to FX) and significantly decreased in Nm01 melanocytes. The RAP1B protein switching between different signaling cascades takes the most abundance in samples Nm01 and M2319 and is strongly inhibited in Am02 melanocytes after exposure to FX.