MAPK and Notch-Mediated Effects of Meso-Xanthin F199 Compounds on Proliferative Activity and Apoptosis of Human Melanocytes in Three-Dimensional Culture

Table 1

The most significantly differed proteins exhibited in the primary culture of human melanocytes cultured under three-dimensional condition (spheroids) for 7 days and exposed to 50 μM equivalent of FX (Am02) or treated with saline solution (Nm01).

Main accession	Recommended protein name	Gene	Ensembl gene ID	Nm-01, FC	Am-02, FC	value
Q06323	Proteasome activator complex subunit 1	PSME1	ENSG00000092010	0.38	0.12
Q99466	Neurogenic locus notch homolog protein 4	NOTCH4	ENSG00000204301	1.17	0.18
Q14203	Dynactin subunit 1	DCTN1	ENSG00000204843	0.64	0.20
P49137	MAP kinase-activated protein kinase 2	MAPKAPK2	ENSG00000162889	1.12	0.22
Q16181	Septin-7	07-Sep		0.75	0.29
P35232	Prohibitin	PHB	ENSG00000167085	0.60	0.30
P55795	Heterogeneous nuclear ribonucleoprotein H2	HNRH2	ENSG00000126945	0.37	0.31
Q15121	Astrocytic phosphoprotein PEA-15	PEA15	ENSG00000162734	0.29	0.32
Q14247	Src substrate cortactin	SRC8	ENSG00000085733	1.62	0.33
Q16647	Prostacyclin synthase	PTGIS	ENSG00000124212	0.66	0.36
Q15149	Plectin	PLEC	ENSG00000178209	0.20	0.40
P63208	S-phase kinase-associated protein 1	SKP1	ENSG00000113558	0.40	0.40
P61978	Heterogeneous nuclear ribonucleoprotein K	HNRPK	ENSG00000165119	0.64	0.41
P14866	Heterogeneous nuclear ribonucleoprotein L	HNRPL	ENSG00000282947	0.84	0.43
P31946	14-3-3 protein beta/alpha	1433B	ENSG00000166913	0.71	0.50
Q00839	Heterogeneous nuclear ribonucleoprotein U	HNRPU	ENSG00000153187	0.91	0.50
Q92499	ATP-dependent RNA helicase DDX1	DDX1	ENSG00000079785	5.08	0.60
Q99623	Prohibitin-2	PHB2	ENSG00000215021	0.42	0.63
O15145	Actin-related protein 2/3 complex subunit 3	ARPC3	ENSG00000111229	2.70	1.03
O15144	Actin-related protein 2/3 complex subunit 2	ARPC2	ENSG00000163466	4.27	1.20
P61224	Ras-related protein Rap-1b	RAP1B	ENSG00000127314	7.98	1.20
Q13200	26S proteasome non-ATPase regulatory subunit 2	PSMD2	ENSG00000175166	2.19	1.37
P52272	Heterogeneous nuclear ribonucleoprotein M	HNRPM	ENSG00000099783	2.62	1.45
Q04917	14-3-3 protein eta	1433F	ENSG00000128245	2.65	1.53
P10415	Apoptosis regulator Bcl-2	BCL2	ENSG00000171791	0.73	1.78
P40121	Macrophage-capping protein	CAPG	ENSG00000042493	2.32	1.79
P42224	Signal transducer and activator of transcription 1-alpha/beta	STAT1	ENSG00000115415	1.32	1.84
P31152	Mitogen-activated protein kinase 4	MAPK4	ENSG00000141639	0.68	1.92
P46531	Neurogenic locus notch homolog protein 1	NOTCH1	ENSG00000148400	0.66	2.13
Q15019	Septin-2	SEPT2		1.05	2.15
P31943	Heterogeneous nuclear ribonucleoprotein H	HNRH1	ENSG00000169045	0.68	2.21
P04792	Heat shock protein beta-1	HSPB1	ENSG00000106211	1.48	2.34
P17980	26S proteasome regulatory subunit 6A	PRS6A	ENSG00000165916	0.48	2.39
P08670	Vimentin	VIME	ENSG00000026025	0.98	2.61
P46940	Ras GTPase-activating-like protein IQGAP1	IQGA1	ENSG00000140575	2.33	2.68
Q9UBI6	Guanine nucleotide-binding protein G/G/G subunit gamma-12	GBG12	ENSG00000172380	1.29	2.73
P78504	Protein jagged-1	JAG1	ENSG00000101384	0.97	2.98
P43686	26S proteasome regulatory subunit 6B	PRS6B	ENSG00000281221	1.45	2.99
Q6NZI2	Caveolae-associated protein 1	CAVN1	ENSG00000177469	1.82	3.56
O95782	AP-2 complex subunit alpha-1	AP2A1	ENSG00000196961	5.14	3.59
O60701	UDP-glucose 6-dehydrogenase	UGDH	ENSG00000109814	0.40	5.54
P60953	Cell division control protein 42 homolog	CDC42	ENSG00000070831	2.14	5.78
Q03135	Caveolin-1	CAV1	ENSG00000105974	5.32	6.18
P07996	Thrombospondin-1	TSP1	ENSG00000137801	3.95	6.58
P62873	Guanine nucleotide-binding protein G/G/G subunit beta-1	GBB1	ENSG00000078369	1.30	20.80