Both Chloroquine and Lopinavir/Ritonavir Are Ineffective for COVID-19 Treatment and Combined Worsen the Pathology: A Single-Center Experience with Severely Ill Patients

Table 1

C-reactive protein levels.

CRP	AUC	Fold increase/decrease	value
Chlo+L/R	674	1.22-fold higher
L/R	337.8	1.63-fold lower
Chlo	264.6	2.08-fold lower
ST	552.2

The area under the curve (AUC) was calculated and compared to that of the ST group. ANOVA tests were performed, considering significant a . L/R: lopinavir/ritonavir; Chlo: chloroquine; L/R+Chlo: lopinavir/ritonavir plus chloroquine; ST: standard treatment; AUC: area under the curve; CRP: C-reactive protein; LDH: lactate dehydrogenase.