Using Elevated Cholesterol Synthesis as a Prognostic Marker in Wilms’ Tumor: A Bioinformatic Analysis

Figure 3

A prognosis model based on differential expressed cholesterol synthesis-related genes (DECSG) could predict the OS of patients with Wilms tumor. (a) Volcano plot presented differentially expressed genes between Chole_high and Chole_low groups. (b) Lasso regression kept 9 genes for the construction of the prognosis model based on the smallest partial likelihood deviance. (c) Survival analysis showed patients with low lasso risk have prolonged survival time. (d) The ROC curve indicated a good accuracy of the prognosis model based on cholesterol synthesis.

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