Bilobalide Enhances AMPK Activity to Improve Liver Injury and Metabolic Disorders in STZ-Induced Diabetes in Immature Rats via Regulating HMGB1/TLR4/NF-κB Signaling Pathway

Figure 1

Effect of bilobalide (BB) supplementation on the liver damage and glucose metabolism in STZ-induced diabetic rats. The one-day-old immature rats or eight-week-old adult rats were randomly allocated to 5 groups (): healthy control, diabetes mellitus model (DM), and drug treatment groups (the rats were intraperitoneally injected with either low (2.5 mg/kg), medium (5 mg/kg), or high (10 mg/kg) dose of bilobalide). (a) The degree of liver damage in immature rats was identified by haematoxylin and eosin (H&E) staining and Suzuki score. (b, c) Glucose and HbA1c levels were determined using commercial kits. (d) The degree of liver damage in adult rats was identified by haematoxylin and eosin (H&E) staining and Suzuki score. (e) The degree of liver damage in immature and adult rats treated with 10 mg/kg bilobalide was identified by haematoxylin and eosin (H&E) staining. (vs. control); ^# (vs. DM); ^## (vs. DM).

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