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| Author | No. of patients (pregabalin/control) | Country | Surgery | Pregabalin group | Outcomes | Jadad score |
|
| Sundar 2012 | 30/30 | India | Coronary artery bypass surgery | Pregabalin 150 mg capsule orally 1 h before surgery | Hemodynamic data, perioperative variables, fentanyl required, visual analog, and Ramsay sedation scores | 4 |
| Anwar 2019 | 50/50 | United Kingdom | Cardiac surgery | Pregabalin (150 mg preoperatively and twice daily for 14 postoperative days) | Pain at 3 and 6 months, total morphine consumption, length of stay in cardiac intensive, sedation score, nausea score, and length of stay in hospital | 5 |
| Ziyaeifard 2015 | 30/30 | Iran | Coronary artery bypass surgery | 150 mg pregabalin capsules | Hemodynamic parameters, morphine consumption, duration of intensive care unit stay, and pain score | 4 |
| Pesonen 2011 | 35/35 | Finland | Cardiac surgery | 150 mg of pregabalin before operation and 75 mg of pregabalin twice daily for 5 postoperative days | MMSE score, RASS score, CAM-ICU scores, P-creatinine, atrial fibrillation, postoperative pain, nausea, and vomiting | 4 |
| Bouzia 2017 | 31/31 | Greece | Cardiac surgery | Pregabalin 150 mg | VRS, morphine, vomiting, intraoperative fentanyl/remifentanil, use of analgesics at 3 months, and sleep disturbance at 3 months | 4 |
| Joshi 2013 | 20/20 | India | Coronary artery bypass surgery | Pregabalin capsules (75 mg) were given every 12 h for 2 postoperative days | Pain characteristics, RASS scale | 4 |
| Borde 2017 | 37/34 | India | Coronary artery bypass surgery | Pregabalin, 150 mg capsule orally, 1 hour before surgery and 2 days postoperatively | Perioperative hemodynamic parameters, QoR-40 dimensions and global score, intravenous fluids, intravenous fentanyl, and durationof surgery | 3 |
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