Altered Genes and Biological Functions in Response to Severe Burns

Figure 3

Protein-protein interaction (PPI) network and biological function of common differentially expressed genes (DEGs) in the three datasets. (a) Common DEGs formed a PPI network and clustered into 13 modules. (b) The coupling between transcription regulators and module genes. (c) Receiver operating characteristic curves for the top 10 module genes showing higher area under the curve (AUC). (d) AUCs of the top 10 genes and their expression in different datasets. (e) The biological processes (BPs) involving module genes. (f) The Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways involving module genes. (g–i) Gene Set Enrichment Analysis to identify KEGG pathways involving DEGs in the datasets (g) GSE19743, (h) GSE37069, or (i) GSE77791.

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