Protective Effect of Thyme Honey against Valproic Acid Hepatotoxicity in Wistar Rats

Table 3

Histological scoring comparison of the groups.

Hepatocyte changes	G1	G2	G3	G4	G5	G6	G7	G8
Hypertrophic degeneration of hepatocytes’ nuclei	-	-	-	-	++++	+++	++	+++
Expansion of hepatocyte sinusoids	-	-	+	+	++++	+++	++	+++
Hepatic fibrosis and necrosis	-	-	+	+	++++	+++	+	++
Inflammation	-	+	+	+	++++	+++	+	+++
Kupffer cell hypertrophy	-	+	+	+	+++	++	++	+++

-: no changes; +: minimum; ++: mild; +++: medium; ++++: severe.