Dendrimers: A New Race of Pharmaceutical Nanocarriers

Table 3

Description of research on dendrimers.

S. No.	Description	Outline	Reference
1	Synthesized prodrug by binding propranolol with lauroyl 3G PAMAM dendrimer and determined the effect of propranolol on adenocarcinoma Caco-2 cells.	Apical to basolateral (A-B) permeability coefficient (Papp) of propranolol was increased, but B-A Papp was decreased. Further observed that A-B Papp was decreased in the presence of colchicine.	[47]
2	Prolonged delivery of ketoprofen using PAMAM dendrimers was attempted by in vitro studies and in vivo studies.	—	[48]
3	Citric acid-polyethylene glycol-citric acid copolymers were prepared, and hydrophobic drugs like mefenamic acid and pyridine were instilled into the guest cavity.	The hydrophobic molecules, when entrapped into hydrophilic cavities, became soluble in aqueous solution.	[49]
4	Aqueous formulation of indomethacin was prepared with increasing concentration of dendrimers to achieve the transdermal drug delivery.	The steady-state flux of the drug increases significantly and was highest with –NH2 dendrimer at 0.2% concentration. Also, in vivo steady-state flux was reached after 5 hrs, and the highest steady-state concentration values were found with –NH2 and –OH dendrimers.	[15]
5	This investigation was carried out to evaluate the potential of PAMAM dendrimers with three different functional group carriers so that they can be used as drug carriers. Drug dendrimer complexes were evaluated for solubility, stability, and in vitro release studies.	The PEGylated polymers showed maximum solubility enhancement followed by amine and hydroxyl dendrimers.	[50]
6	The gel formulations of 1%, 3%, and 5% (wt/wt) of SPL7013 (dendrimer having antiviral activity) were prepared and evaluated for the vaginal and rectal safety profile.	The vaginal safety profile of the 1% & 3% gel containing polymer were the same, but they were superior to that of 5%. The rectal safety profile of 3% gel was also good so they can be used for internal use.	[51]