Suppression of lncRNA MALAT1 Reduces LPS- or IL-17A-Induced Inflammatory Response in Human Middle Ear Epithelial Cells via the NF-κB Signaling Pathway

Figure 5

MALAT1 promotes LPS- or IL-17A-induced inflammatory response through the NF-κB pathway. (a) The overexpression efficacy of pcDNA3.1/MALAT1 in HMEECs was detected by RT-qPCR analysis. (b–g) The effects of MALAT1 and QNZ on concentrations of inflammatory cytokines (TNF-α, IL-β, and IL-6) were evaluated by ELISA assay in HMEECs under LPS or IL-17A treatment. (h, i) The effects of MALAT1 and QNZ on protein levels of MUC5AC and MUC8 were measured by western blot in LPS- or IL-17A-induced HMEECs. , .

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