Research Article
Effects of Remimazolam and Propofol on Ca2+ Regulation by Ryanodine Receptor 1 with Malignant Hyperthermia Mutation
Table 1
The Fura-2 ratio (340/380 nm) of HEK-293 cells expressing wild-type or mutation RYR1 at resting state and at response to 10 mM and 20 mM caffeine. There was no statistically significant difference in the Fura-2 ratio at resting, response to 10 mM caffeine, or response to 20 mM caffeine between wild-type RYR1-expressed HEK-293 cells and mutated RYR1-expressed HEK-293 cells. There is no statistical difference between the response to 10 mM caffeine and the response to 20 mM caffeine in the Fura-2 ratio for any RYR1 ( value response of 10 mM caffeine vs. 20 mM caffeine is wild-type RYR1: 0.711667, p.Thr84Met: 0.777066, p.Ser2345Arg: 0.924708, and p.Ala4894Thr: 0.834281, respectively).
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