Inhibition of SDF-1/CXCR4 Axis to Alleviate Abnormal Bone Formation and Angiogenesis Could Improve the Subchondral Bone Microenvironment in Osteoarthritis

<div>(a, b) Immunofluorescent staining and quantitative analysis of SDF-1 in subchondral bone shows SDF-1 significantly elevates in the ACLT groups. Scale bar, 50 <i>μ</i>m. (c) Representative three-dimensional micro-CT images of sagittal views of the tibia subchondral bone medial compartment. (d–g) 3D parameter analysis of the tibia subchondral bone. (h, i) Safranin O and fast green staining shows proteoglycan loss and cartilage degeneration and the OARSI score for each group. Scale bar, 50 <i>μ</i>m. (j) H&amp;E staining shows calcified cartilage (CC) and hyaline cartilage (HC) thickness marked by double-headed arrows. Scale bars, 50 <i>μ</i>m. 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BioMed Research International

fig1

Figure 1

Figure 1: Inhibition of SDF-1/CXCR4 Axis to Alleviate Abnormal Bone Formation and Angiogenesis Could Improve the Subchondral Bone Microenvironment in Osteoarthritis 

Figure 1 | Inhibition of SDF-1/CXCR4 Axis to Alleviate Abnormal Bone Formation and Angiogenesis Could Improve the Subchondral Bone Microenvironment in Osteoarthritis 