|
| lncRNAs | Location | Expression | Drugs | Mechanism | References |
|
| AK022798 | — | Upregulated | Cisplatin | Notch 1 can promote the lncRNA AK022798 expression and result in the formation of SGC7901/cisplatin and BGC823/cisplatin cells. | [133] |
| BCAR4 (breast cancer anti-estrogen resistance 4) | 16p13.13 | Upregulated | Cisplatin | Overexpression of BCAR4 in SGC7901 cells increased resistance to cisplatin, while reduced BCAR4 expression increased the sensitivity of SGC7901/cisplatin cells to cisplatin. | [134] |
| CASC2 (cancer susceptibility 2) | 10q26.11 | Downregulated | Cisplatin | CASC2 overexpression overcame cisplatin resistance in gastric cancer by sponging miR-19a. | [135] |
| CASC9 (cancer susceptibility 9) | 8q21.13 | Upregulated | Paclitaxel, adriamycin | CASC9 knockdown restored chemosensitivity to paclitaxel and adriamycin by decreasing the expression of MDR1protein. | [136] |
| GHET1 (gastric carcinoma proliferation enhancing transcript 1) | 7q36.1 | Upregulated | Cisplatin | Highly expressing GHET1 promoted the development of MDR, which was related to the Bax, Bcl-2, MDR1, and MRP1 gene expression in gastric cancer cells. | [137] |
| LEIGC | — | Downregulated | 5-Fluorouracil | Overexpression of LEIGC suppressed tumor growth and cell proliferation and enhanced the sensitivity of gastric cancer cells to 5-fluorouracil, whereas knockdown of LEIGC showed the opposite effect. | [138] |
| MALAT1 (metastasis-associated lung adenocarcinoma transcript 1) | 11q13.1 | Upregulated | Vincristine, cisplatin | MALAT1 acts as a competing endogenous RNA for miR-23b-3p and attenuates the inhibitory effect of miR-23b-3p on ATG12, leading to chemo-induced autophagy and chemoresistance in GC cells. | [139] |
| MRUL (also named DMTF1, cyclin D-binding myb-like transcription factor 1) | 7q21.12 | Upregulated | MDR | MRUL depletion reduced ABCB1 mRNA levels in a dose- and time-dependent manner, and ABCB1 was responsible for drug transporters. | [140] |
| PTV1 (polytropic virus 1) | — | Upregulated | Cisplatin | Overexpression of lncRNA PVT1 in gastric carcinoma promotes the development of MDR. | [141] |
| XLOC_006753 | — | Upregulated | MDR | High expression of XLOC_006753 promoted the development of MDR, which was activated by the PI3K/AKT/mTOR pathway in GC cells. | [142] |
| ZFAS (zinc finger antisense) | Chromosome 8 | Upregulated | Cisplatin, paclitaxel | The silencing of ZFAS1 inhibited the growth, proliferation, cell cycle progress, migration, invasion, EMT, and chemotherapeutic tolerance by blocking the Wnt/β-catenin signaling in gastric cancer cells. | [143] |
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