Research Article
Diagnostic and Prognostic Value of Long Noncoding RNAs as Potential Novel Biomarkers in Intrahepatic Cholestasis of Pregnancy
Table 4
GO and pathway enriched analyses for differently expressed lncRNAs and mRNAs.
| Category | Subcategory | value | No. of genes | No. of target genes |
| Pathways | Primary bile acid biosynthesis | | 36 | 6 | Oxidative stress | | 69 | 15 | Fatty acid biosynthesis | | 53 | 9 | Inflammation mediated by chemokine and cytokine signaling pathway | | 77 | 15 |
| GO: biological function | Response to fatty acid | | 61 | 13 |
| | Cell cycle | | 61 | 15 | Neuron apoptotic process | | 70 | 15 | Endothelial cell proliferation | | 72 | 14 | Cell cycle process | | 48 | 10 | Apoptotic DNA fragmentation | | 63 | 14 | Mitotic cell cycle arrest | | 63 | 12 | Adaptive immune response | | 38 | 8 | Cell cycle checkpoint | | 69 | 15 | Activation of cysteine-type endopeptidase activity involved in apoptotic process | | 70 | 15 | Cell differentiation | | 44 | 10 | Very long-chain fatty acid metabolic process | | 29 | 6 | Innate immune response | | 75 | 15 | Long-chain fatty acyl CoA biosynthetic process | | 60 | 12 | Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress | | 57 | 13 | Extrinsic apoptotic signaling pathway | | 54 | 9 | Oxidative stress | | 67 | 14 | Cysteine-type endopeptidase activity involved in apoptotic process | | 70 | 15 | Fatty acid metabolic process | | 60 | 11 | Fatty acid biosynthetic process | | 29 | 6 | Intrinsic apoptotic signaling pathway | | 72 | 14 |
|
|