Diagnostic and Prognostic Value of Long Noncoding RNAs as Potential Novel Biomarkers in Intrahepatic Cholestasis of Pregnancy

Table 4

GO and pathway enriched analyses for differently expressed lncRNAs and mRNAs.

Category	Subcategory	value	No. of genes	No. of target genes
Pathways	Primary bile acid biosynthesis		36	6
	Oxidative stress		69	15
	Fatty acid biosynthesis		53	9
	Inflammation mediated by chemokine and cytokine signaling pathway		77	15
GO: biological function	Response to fatty acid		61	13
	Cell cycle		61	15
	Neuron apoptotic process		70	15
	Endothelial cell proliferation		72	14
	Cell cycle process		48	10
	Apoptotic DNA fragmentation		63	14
	Mitotic cell cycle arrest		63	12
	Adaptive immune response		38	8
	Cell cycle checkpoint		69	15
	Activation of cysteine-type endopeptidase activity involved in apoptotic process		70	15
	Cell differentiation		44	10
	Very long-chain fatty acid metabolic process		29	6
	Innate immune response		75	15
	Long-chain fatty acyl CoA biosynthetic process		60	12
	Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress		57	13
	Extrinsic apoptotic signaling pathway		54	9
	Oxidative stress		67	14
	Cysteine-type endopeptidase activity involved in apoptotic process		70	15
	Fatty acid metabolic process		60	11
	Fatty acid biosynthetic process		29	6
	Intrinsic apoptotic signaling pathway		72	14