Associations between Inflammatory Cytokine Gene Polymorphisms and Susceptibilities to Intracranial Aneurysm in Chinese Population
Table 2
Multivariate logistic regression analysis of associations between inflammatory cytokine gene polymorphisms and risk of IA in Chinese population.
Gene
SNPs
Genotype
Dominant model
Recessive model
Additive model
PHWE†
Case ()
Control ()
OR (95% CI)
OR (95% CI)
OR (95% CI)
IL-1A
rs17561C>A
341/41/2
318/65/1
0.68 (0.41-1.12)
0.132
1.54 (0.10-23.79)
0.757
0.71 (0.44-1.15)
0.163
0.218
IL-1B
rs1143627G>A
77/199/108
93/185/106
1.28 (0.83-1.96)
0.267
1.09 (0.73-1.61)
0.677
1.13 (0.88-1.45)
0.359
0.489
rs16944A>G
71/196/117
88/187/109
1.33 (0.86-2.08)
0.204
1.19 (0.81-1.74)
0.385
1.18 (0.92-1.52)
0.195
0.651
rs1143623C>G
134/185/65
144/179/61
1.00 (0.69-1.44)
0.986
0.93 (0.57-1.52)
0.773
0.98 (0.76-1.26)
0.870
0.666
rs1143630T>G
12/108/264
13/102/269
1.37 (0.51-3.68)
0.538
1.09 (0.74-1.61)
0.657
1.10 (0.79-1.53)
0.559
0.391
rs2853550A>G
0/58/326
5/75/304
—
—
1.23 (0.79-1.94)
0.363
1.31 (0.85-2.01)
0.220
0.878
rs3136558A>G
160/176/48
171/172/41
0.91 (0.63-1.30)
0.587
0.84 (0.48-1.49)
0.559
0.91 (0.70-1.19)
0.493
0.817
IL-6
rs1800795C>G
0/0/384
0/0/384
—
—
—
—
—
—
—
rs1800796G>C
17/137/230
18/141/225
1.27 (0.55-2.97)
0.579
0.98 (0.69-1.41)
0.918
1.02 (0.75-1.38)
0.909
0.491
IL-12B
rs3181216A>T
207/152/25
191/155/38
0.77 (0.54-1.10)
0.147
0.46 (0.23-0.89)
0.022
0.74 (0.56-0.98)
0.034
0.429
rs3212227T>G
105/191/88
107/195/82
1.00 (0.67-1.48)
0.994
1.13 (0.74-1.72)
0.570
1.04 (0.81-1.34)
0.741
0.696
rs1003199C>T
131/208/45
148/190/46
1.24 (0.86-1.80)
0.253
1.02 (0.59-1.78)
0.932
1.13 (0.86-1.49)
0.372
0.205
rs2195940C>T
354/28/2
341/41/2
0.55 (0.30-1.04)
0.065
0.76 (0.06-9.50)
0.828
0.59 (0.33-1.06)
0.079
0.528
TNF-α
rs1800629G>A
337/46/1
342/41/1
1.14 (0.67-1.96)
0.632
1.48 (0.04-54.63)
0.831
1.14 (0.68-1.93)
0.620
0.844
rs1799724C>T
293/86/5
298/77/9
1.02 (0.67-1.54)
0.944
0.60 (0.16-2.23)
0.444
0.97 (0.67-1.40)
0.868
0.141
rs1799964T>C
272/102/10
252/112/20
0.67 (0.46-0.98)
0.041
0.58 (0.24-1.41)
0.230
0.71 (0.51-0.98)
0.034
0.111
SNPs: single nucleotide polymorphisms; OR: odds ratio; CI: confidence interval; HWE: Hardy-Weinberg equilibrium. Genotype presented as wild type/heterozygous/homozygous, †HWE value for the control group.
