Associations between Inflammatory Cytokine Gene Polymorphisms and Susceptibilities to Intracranial Aneurysm in Chinese Population
Table 3
Multivariate logistic regression analysis of associations between inflammatory cytokine gene polymorphisms and risk of single IA in Chinese population.
Gene
SNPs
Genotype
Dominant model
Recessive model
Additive model
PHWE†
Case ()
Control ()
OR (95% CI)
OR (95% CI)
OR (95% CI)
IL-1A
rs17561
224/23/1
318/65/1
0.52 (0.28-0.97)
0.040
2.37 (0.15-38.57)
0.543
0.57 (0.32-1.03)
0.064
0.218
IL-1B
rs1143627
48/126/74
93/185/106
1.18 (0.72-1.93)
0.523
1.21 (0.77-1.90)
0.400
1.14 (0.86-1.53)
0.362
0.489
rs16944
44/128/76
88/187/109
1.28 (0.77-2.15)
0.340
1.22 (0.78-1.90)
0.387
1.18 (0.88-1.58)
0.265
0.651
rs1143623
91/115/42
144/179/61
0.92 (0.60-1.40)
0.683
1.09 (0.62-1.90)
0.770
0.98 (0.73-1.32)
0.895
0.666
rs1143630
8/68/172
13/102/269
1.47 (0.45-4.75)
0.524
1.01 (0.65-1.57)
0.971
1.05 (0.72-1.53)
0.805
0.391
rs2853550
0/35/213
5/75/304
—
—
1.56 (0.91-2.69)
0.110
1.61 (0.96-2.71)
0.074
0.878
rs3136558
99/115/34
171/172/41
1.05 (0.70-1.59)
0.812
0.93 (0.48-1.77)
0.813
1.01 (0.74-1.38)
0.949
0.817
IL6
rs1800795
0/0/248
0/0/384
—
—
—
—
—
—
—
rs1800796
10/84/154
18/141/225
1.37 (0.50-3.76)
0.537
1.07 (0.71-1.62)
0.747
1.09 (0.77-1.55)
0.621
0.491
IL12B
rs3181216
136/97/15
191/155/38
0.80 (0.53-1.20)
0.274
0.41 (0.18-0.93)
0.033
0.75 (0.54-1.03)
0.073
0.429
rs3212227
77/116/55
107/195/82
0.89 (0.57-1.38)
0.593
1.04 (0.64-1.70)
0.862
0.97 (0.73-1.28)
0.811
0.696
rs1003199
84/130/34
148/190/46
1.11 (0.73-1.71)
0.621
0.88 (0.46-1.69)
0.706
1.03 (0.75-1.41)
0.855
0.205
rs2195940
226/20/2
341/41/2
0.71 (0.35-1.43)
0.340
1.00 (0.08-12.85)
0.998
0.75 (0.40-1.43)
0.383
0.528
TNF-α
rs1800629
218/29/1
342/41/1
1.27 (0.69-2.35)
0.443
2.12 (0.05-85.22)
0.691
1.27 (0.71-2.30)
0.422
0.844
rs1799724
187/60/1
298/77/9
0.95 (0.59-1.53)
0.824
0.03 (0.00-2.93)
0.135
0.86 (0.55-1.33)
0.488
0.141
rs1799964
168/75/5
252/112/20
0.70 (0.45-1.09)
0.116
0.38 (0.11-1.26)
0.113
0.70 (0.48-1.02)
0.060
0.111
SNPs: single nucleotide polymorphisms; OR: odds ratio; CI: confidence interval; HWE: Hardy-Weinberg equilibrium. Genotype presented as wild type/heterozygous/homozygous. †HWE value for the control group.
