Associations between Inflammatory Cytokine Gene Polymorphisms and Susceptibilities to Intracranial Aneurysm in Chinese Population
Table 4
Multivariate logistic regression analysis of associations between inflammatory cytokine gene polymorphisms and risk of multiple IAs in Chinese population.
Gene
SNPs
Genotype
Dominant model
Recessive model
Additive model
PHWE†
Case ()
Control ()
OR (95% CI)
OR (95% CI)
OR (95% CI)
IL-1A
rs17561
117/18/1
318/65/1
1.18 (0.59-2.36)
0.635
0.33 (0.00-107.13)
0.710
1.15 (0.59-2.26)
0.681
0.218
IL-1B
rs1143627
29/73/34
93/185/106
1.23 (0.64-2.38)
0.534
0.93 (0.52-1.68)
0.806
1.04 (0.71-1.52)
0.835
0.489
rs16944
27/68/41
88/187/109
1.25 (0.64-2.45)
0.512
1.20 (0.68-2.11)
0.537
1.16 (0.80-1.70)
0.434
0.651
rs1143623
43/70/23
144/179/61
1.16 (0.67-2.02)
0.594
0.84 (0.39-1.80)
0.654
1.03 (0.70-1.51)
0.887
0.666
rs1143630
4/40/92
13/102/269
1.21 (0.29-4.99)
0.795
1.24 (0.69-2.22)
0.479
1.19 (0.73-1.95)
0.494
0.391
rs2853550
0/23/113
5/75/304
—
—
0.75 (0.39-1.42)
0.371
0.84 (0.47-1.52)
0.568
0.878
rs3136558
61/61/14
171/172/41
0.67 (0.39-1.14)
0.137
0.65 (0.26-1.61)
0.347
0.72 (0.47-1.09)
0.118
0.817
IL6
rs1800795
0/0/136
0/0/384
—
—
—
—
—
—
—
rs1800796
7/53/76
18/141/225
1.10 (0.32-3.73)
0.879
0.88 (0.52-1.49)
0.640
0.93 (0.60-1.44)
0.737
0.491
IL12B
rs3181216
71/55/10
191/155/38
0.68 (0.40-1.15)
0.150
0.58 (0.23-1.47)
0.249
0.72 (0.48-1.08)
0.109
0.429
rs3212227
28/75/33
107/195/82
1.21 (0.66-2.22)
0.532
1.32 (0.72-2.43)
0.369
1.20 (0.82-1.74)
0.352
0.696
rs1003199
47/78/11
148/190/46
1.35 (0.76-2.38)
0.307
1.10 (0.49-2.48)
0.814
1.20 (0.80-1.81)
0.381
0.205
rs2195940
128/8/0
341/41/2
0.28 (0.09-0.89)
0.031
—
—
0.28 (0.09-0.90)
0.032
0.528
TNF-α
rs1800629
119/17/0
342/41/1
1.05 (0.47-2.36)
0.910
—
—
1.04 (0.47-2.32)
0.923
0.844
rs1799724
106/26/4
298/77/9
1.16 (0.64-2.09)
0.624
1.79 (0.44-7.26)
0.417
1.19 (0.72-1.96)
0.493
0.141
rs1799964
104/27/5
252/112/20
0.54 (0.30-0.97)
0.040
0.95 (0.30-2.96)
0.928
0.67 (0.41-1.07)
0.095
0.111
SNPs: single nucleotide polymorphisms; OR: odds ratio; CI: confidence interval; HWE: Hardy-Weinberg equilibrium. Genotype presented as wild type/heterozygous/homozygous. †HWE value for the control group.
