Inhibitory Activity of Pyrroloisoxazolidine Derivatives against Chlamydia trachomatis

Figure 4

Compounds 1 and 2 weakly attenuated the EB infectivity. Chlamydia trachomatis L2 EBs were incubated with 2, 8, or 32 μM compound 1 (a) or 2 (b) at 37°C or 4°C for 1 or 4 h. After washes, EBs were used to infect HeLa cell. At 36 hpi, the inclusion was counted as described in “Materials and Methods.” Data are presented as of three independent assays. , compared 4°C with 37°C by Student’s -tests. ^#, compared with each DMSO control sample by Student’s -tests.

(a)

(b)