Inhibitory Activity of Pyrroloisoxazolidine Derivatives against Chlamydia trachomatis

Table 1

The IC₅₀ values (μM) and cell viability of pyrroloisoxazolidine-treated uninfected cells. IC₅₀ values are presented as the mean (95% confidence interval). indicates statistically significant () difference of cell proliferation activity between compound-treated and DMSO-treated cells.

Entry					IC50 (μM) Mean (95% confidence interval)		Cell viability (%)
	R^1	R^2	R^3	R^4	Ct L2	Ct D	32 μM
1	Ph	Ph	Ph	Ph	7.25 (6.48 ~ 8.11)	9.31 (8.42 ~ 10.28)	100.92
2	Ph		Ph	Ph	8.69 (7.59 ~ 9.93)	9.73 (8.83 ~ 10.72)	98.32
3	Ph	Ph		Ph	8.67 (6.40 ~ 11.73)	20.91 (17.80 ~ 24.58)	99.89
4	Ph			Ph	11.17 (7.49 ~ 16.64)	>32	97.49
5	Ph			Ph	15.49 (8.04 ~ 29.87)	>32	95.17
6	Ph			Ph	9.08 (4.66 ~ 17.68)	16.85 (12.61 ~ 22.52)
7	Ph	Ph		Ph	19.06 (12.84 ~ 28.30)	>32
8	Ph			Ph	25.42 (12.62 ~ 51.22)	28.60 (18.77 ~ 43.58)	101.81
9				Ph	>32	19.59 (13.18 ~ 29.11)	96.51
10				Ph	17.35 (13.02 ~ 23.10)	15.43 (12.94 ~ 18.40)
11		Ph		Ph	>32	23.54 (16.13 ~ 34.35)	99.70
12		Ph		Ph	17.52 (11.07 ~ 27.73)	12.51 (9.86 ~ 15.87)	103.85
13	Ph			Ph	>32	16.29 (12.03 ~ 22.06)	95.73
14		Ph		Ph	16.78 (13.61 ~ 20.70)	16.31 (12.81 ~ 20.77)	97.95
15		Ph		Ph	9.77 (8.45 ~ 11.30)	12.22 (7.94 ~ 18.80)	103.64
16			Ph	Ph	13.52 (12.86 ~ 14.21)	5.93 (4.51 ~ 7.79)	96.53
17		Ph		Ph	>32	27.57 (20.56 ~ 36.98)	113.63
18				Ph	>32	20.97 (16.41 ~ 26.79)	105.86