Research Article
Epidemiology of Drug- and Herb-Induced Liver Injury Assessed for Causality Using the Updated RUCAM in Two Hospitals from China
Table 4
Comparison of liver tests improvement ≥50% and <50% after 1 week (±2 days) of AIHPAs treatment.
| | Variable (, (%)) | Liver tests improvement after 1 week (±2 days) AIHPAs treatment | | | | ≥50% | <50% |
| | Age (years) | | | -1.170 | 0.245 | | The first set of ALT level (IU/L) | | | 237.500 | ≤0.001 | | The first set of ALP level (IU/L) | | | 1277.500 | ≤0.001 | | The first set of TBIL level (μmol/L) | | | 672.500 | 0.226 | | Gender | | | | | | Male | 26 (31.70) | 18 (21.95) | 0.012 | 0.913 | | Female | 22 (26.83) | 16 (19.51) | | Types | | | | | | Hepatocellular | 44 (53.66) | 7 (8.54) | 46.653 | ≤0.001 | | Cholestatic | 3 (3.66) | 21 (25.61) | | Mixed | 1 (1.22) | 6 (7.32) | | Severity of DILI and HILI | | | | | | Grade 1 | 28 (34.57) | 23 (28.40) | 0.560 | 0.454 | | Grade 2 | 9 (11.11) | 4 (4.94) | | Grade 3 | 5 (6.17) | 6 (7.41) | | Grade 4 | 5 (6.17) | 1 (1.23) | | Treatment by AIHPAs | | | | | | Monotherapy | 5 (6.10) | 3 (3.66) | 0.746 | 0.388 | | Combination with 2 drugs | 12 (14.63) | 14 (17.07) | | Combination with drugs ≥3 | 31 (37.80) | 17 (20.73) |
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