| Biomarker | Normal range | Median (IQR) | value | All patients (254) | Survivors (203) | Nonsurvivors (51) |
| Leucocytes, ×109/L | 3.5-9.5 | 6.20 (4.81-8.93) | 5.87 (4.64-7.27) | 10.66 (6.29-13.4) | <0.001 | Increased | 56 (22.0%) | 26 (12.8%) | 30 (58.8%) | <0.001 | Decreased | 14 (5.5%) | 12 (5.9%) | 2 (3.9%) | | Neutrophils, ×109/L | 1.8-6.3 | 4.38 (3.17-7.26) | 3.96 (2.80-5.31) | 9.48 (5.87-12.59) | <0.001 | Increased | 75 (29.5%) | 37 (18.2%) | 38 (74.5%) | <0.001 | Decreased | 10 (3.9%) | 9 (4.4%) | 1 (2.0%) | | Lymphocytes, ×109/L | 1.1-3.2 | 0.96 (0.64-1.40) | 1.09 (0.74-1.51) | 0.56 (0.43-0.73) | <0.001 | Decreased | 151 (59.4%) | 102 (50.2%) | 49 (96.1%) | <0.001 | NLR | 1.6-5.7 | 4.8 (2.3-9.6) | 3.7 (2.0-6.1) | 15.3 (9.6-26.9) | <0.001 | Decreased | 24 (9.4%) | 24 (11.8%) | — | 0.003 | Increased | 106 (41.7%) | 57 (28.1%) | 49 (96.1%) | | Monocyte, ×109/L | 0.1-0.6 | 0.49 (0.36-0.63) | 0.51 (0.40-0.64) | 0.37 (0.28-0.59) | 0.002 | Platelets, mean (SD), ×109/L | 125-350 | | | | <0.001 | Increased | 31 (12.2%) | 30 (14.8%) | 1 (2.0%) | <0.001 | Decreased | 38 (15.0%) | 21 (10.3%) | 17 (33.3%) | | ESR, mm/H | 0-20 mm/H | 40 (18.5-64.0) | 41 (20-66) | 36 (15-63) | 0.299 | Glu, mmol/L | 4.11-6.05 | 6.13 (5.29-8.07) | 5.83 (5.16-7.20) | 8.99 (6.65-11.77) | <0.001 | NT-proBNP, pg/mL | <738 | 244 (96.2-849.8) | 192 (74-540) | 1235 (601-4390) | <0.001 | PCT, ng/mL | 0.02-0.05 | 0.06 (0.03-0.16) | 0.04 (0.03-0.10) | 0.22 (0.12-1.01) | <0.001 | cTnI, pg/mL | ≤15.6 | 6.6 (2.5-24.2) | 4.5 (2.2-11.9) | 94.7 (22.0-908.7) | <0.001 | Myoglobin, ng/mL | ≤106 | 56.2 (34.1-119.7) | 48.6 (31.2-89.4) | 160.0 (82.6-442.9) | <0.001 | CK-MB, ng/mL | ≤3.4 | 0.8 (0.5-1.8) | 0.7 (0.4-1.4) | 2.8 (1.4-7.4) | <0.001 | Blood biochemistry | ALT, U/mL | ≤33 | 24.5 (15.8-42.0) | 23 (15-40) | 29 (19-50) | 0.023 | AST, U/mL | ≤32 | 26.0 (19.0-45.0) | 24 (18-37) | 47 (30-79) | <0.001 | TP, g/L | 64-83 | 68.6 (64.4-72.8) | 69.3 (65.4-73.6) | 63.8 (56.9-70.5) | <0.001 | Albumin, g/L | 35-53 | 33.2 (30.5-37.5) | 34.6 (31.4-38.1) | 29.7 (25.3-32.5) | <0.001 | Globulin, U/mL | 25-35 | 34.1 (30.6-38.1) | 34.0 (31.4-38.1) | 34.3 (31.3-38.6) | 0.946 | TBIL, μmol/L | ≤2 | 10.5 (7.2-14.6) | 9.5 (7.0-13.9) | 14.0 (9.6-19.2) | <0.001 | DBIL, μmol/L | ≤8 | 4.4 (3.1-6.6) | 4.1 (3.0-5.7) | 6.2 (4.4-10.2) | <0.001 | IBIL, μmol/L | ≤12.9 | 5.4 (4.1-8.2) | 5.2 (3.9-7.9) | 6.5 (4.5-9.2) | 0.046 | ALP, U/L | 35-105 | 71 (55-93) | 67 (55-87) | 84 (58-122) | 0.003 | GGT, U/L | 6-42 | 30 (19-54.5) | 29 (18-52) | 40 (20-81) | 0.046 | TC, mmol/L | <5.18 | 3.77 (3.12-4.41) | 3.9 (3.3-4.5) | 3.2 (2.7-3.9) | <0.001 | LDH, U/L | 135-214 | 292.5 (227.8-453.0) | 265 (214-351) | 532 (469-760) | <0.001 | Creatinine, μmol/L | 45-85 | 74 (60-92.5) | 71 (59-88) | 88 (69-160) | <0.001 | CRP, mg/L | <1 | 28.1 (4.8-92.5) | 13.8 (2.5-61) | 102.9 (62.5-187.1) | <0.001 | | Increased | 216 (85.0%) | 165 (86.8%) | 51 (100.0%) | 0.003 | Coagulation function | PT, s | 11.5-14.5 | 14.0 (13.4-14.9) | 13.8 (13.2-14.3) | 15.5 (14.6-18.1) | <0.001 | INR | 0.8-1.2 | 1.08 (1.01-1.17) | 1.05 (0.99-1.11) | 1.22 (1.14-1.47) | <0.001 | Fibrinogen, g/L | 2-4 | 5.00 (3.42-6.08) | 5.08 (3.71-6.13) | 3.92 (2.61-5.82) | 0.004 | APTT, s | 29-42 | 39.1 (36.1-43.4) | 39 (36.2-43.0) | 39.1 (35.7-45.1) | 0.984 | D-dimer, U/mL FEU | <0.5 | 1.46 (0.57-4.05) | 1.18 (0.48-2.18) | 15.01 (1.77-21.00) | <0.001 | Urine routine | Urine protein, n/ (%) | — | 123/225 (54.7%) | 84/185 (45.4%) | 39/40 (97.5%) | <0.001 | USG, n, median (IQR) | 1.01-1.025 | 225, 1.016 (1.012-1.022) | 185, 1.015 (1.011-1.020) | 40, 1.021 (1.018-1.028) | <0.001 | pH, n, median (IQR) | 4.5-8.0 | 225, 6.5 (6.0-6.5) | 185, 6.5 (6.0-6.75) | 40, 6.0 (6.0-6.5) | 0.039 | KET, n/ (%) | — | 37/225 (16.4%) | 18/185 (9.7%) | 19/40 (47.5%) | <0.001 | URO, n/ (%) | — | 12/225 (5.3%) | 6/185 (3.2%) | 6/40 (15.0%) | 0.009 | Arterial blood gas | pH, , median (IQR) | 7.35-7.45 | 77, 7.42 (7.39-7.46) | 58, 7.41 (7.39-7.45) | 19, 7.42 (7.38-7.48) | 0.382 | PaCO2, mmHg | 35-45 | 76, 38.8 (34.4-43.2) | 57, 40.7 (37.4-43.7) | 19, 31.9 (25.3-37.4) | <0.001 | PaO2, mmHg | 80-100 | 76, 117 (78.5-174.8) | 57, 134 (87.2-187) | 19, 68 (51.7-121) | <0.001 | SB, mmol/L | 21-25 | 75, 25.3 (23.5-27.2) | 56, 25.4 (23.9-27.3) | 19, 22.2 (19.0-25.3) | 0.001 | BE, mmol/L | -3-3 | 76, 0.8 (-1.3-3.2) | 57, 1.3 (-0.5-3.3) | 19, -3.9 (-8.1-0.2) | 0.001 | TCO2, mmol/L | 24-32 | 75, 22.5 (20.2-24.2) | 56, 23.0 (21.4-24.4) | 19, 17.8 (16.0-22.5) | 0.001 | SaO2, , median (IQR) | 91.9-99% | 76, 98.6 (94.0-99.6) | 57, 99.1 (97.2-99.6) | 19, 89.8 (85.1-97.5) | <0.001 |
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