Association of BTLA Polymorphisms with Susceptibility to Non-Small-Cell Lung Cancer in the Chinese Population
Table 6
Stratified analyses between BTLA rs2171513 G>A polymorphism and NSCLC risk by sex, age, smoking status, alcohol consumption, and BMI.
Variable
BTLA rs2171513 G>A (case/control)a
Adjusted ORb (95% CI); P
GG
GA
AA
GG
GA vs. GG
AA vs. GG
GA/AA vs. GG
AA vs. (GG/GA)
Sex
Male
335/361
165/165
15/24
1.00
1.15 (0.86-1.53); : 0.346
0.70 (0.34-1.43); : 0.325
1.09 (0.83-1.44); : 0.545
0.67 (0.33-1.36); : 0.266
Female
319/221
132/111
24/13
1.00
0.84 (0.61-1.15); : 0.273
1.32 (0.65-2.69); : 0.441
0.89 (0.66-1.20); : 0.445
1.40 (0.69-2.83); : 0.350
Age
<59
305/265
133/114
21/14
1.00
1.02 (0.73-1.40); : 0.930
1.58 (0.73-3.42); : 0.244
1.06 (0.78-1.46); : 0.672
1.58 (0.73-3.39); : 0.244
≥59
349/317
164/162
18/23
1.00
0.98 (0.74-1.30); : 0.906
0.67 (0.35-1.30); : 0.240
0.94 (0.72-1.23); : 0.659
0.68 (0.35-1.30); : 0.242
Smoking status
Never
408/456
188/227
29/28
1.00
0.97 (0.76-1.24); : 0.803
1.18 (0.67-2.08); : 0.571
0.99 (0.78-1.26); : 0.948
1.19 (0.68-2.09); : 0.543
Ever
246/126
109/49
10/9
1.00
1.08 (0.72-1.63); : 0.698
0.58 (0.23-1.48); : 0.254
1.01 (0.68-1.48); : 0.980
0.57 (0.22-1.44); : 0.232
Alcohol consumption
Never
520/520
226/245
34/34
1.00
0.98 (0.78-1.23); : 0.829
0.99 (0.59-1.66); : 0.967
0.98 (0.79-1.22); : 0.834
1.00 (0.60-1.66); : 0.990
Ever
134/62
71/31
5/3
1.00
1.13 (0.65-1.95); : 0.670
0.79 (0.17-3.69); : 0.767
1.10 (0.64-1.87); : 0.735
0.76 (0.17-3.50); : 0.725
BMI (kg/m2)
<24
441/326
194/147
26/20
1.00
1.05 (0.80-1.38); : 0.711
0.91 (0.49-1.69); : 0.761
1.03 (0.80-1.34); : 0.803
0.89 (0.48-1.66); : 0.724
≥24
213/256
103/129
13/17
1.00
0.93 (0.66-1.30); : 0.656
1.09 (0.49-2.40); : 0.839
0.94 (0.68-1.30); : 0.723
1.11 (0.51-2.44); : 0.791
Notes: athe genotyping was successful in 1,003 (98.70%) NSCLC cases, and 901 (99.33%) controls for BTLA rs2171513 G>A. bAdjusted for age, sex, smoking status, alcohol consumption, and BMI (besides stratified factors accordingly) in a logistic regression model. Abbreviations: BMI: body mass index; NSCLC: non-small-cell lung cancer.
