Specific Cytokine Profiles Predict the Severity of Influenza A Pneumonia: A Prospectively Multicenter Pilot Study

Table 4

ROC curve analysis of various indicators to predict IPPV in patients with influenza A pneumonia.

	Cutoff points	AUC	95% CI		Sensitivity (%)	Specificity (%)
IL-4/IL-17A	>4.97	0.940	0.805-0.992	<0.001	88.89	92.31
NLR	>6.57	0.897	0.748-0.974	<0.001	88.89	88.46
PaO2/FiO2	≤110	0.795	0.625-0.912	0.002	55.56	96.15
CURB-65	>1	0.795	0.625-0.912	<0.001	55.56	92.31
PSI	>102	0.786	0.615-0.906	0.002	66.67	92.31

Abbreviations: IPPV: intermittent positive pressure ventilation; AUC: area under curve; CI: confidence interval; IL: interleukin; NLR: neutrophil/lymphocyte ratio; PSI: pneumonia severity index.