Research Article
Relationship of PD-1 (PDCD1) and PD-L1 (CD274) Single Nucleotide Polymorphisms with Polycystic Ovary Syndrome
Table 4
Allele frequency distributions of PD-L1 and PD-1 gene SNP loci in the PCOS and control groups.
| | Gene | SNP | Allele | PCOS () | Control () | | |
| | PD-L1 gene | rs6415794 | T
A | 456 (69.05)
204 (30.95) | 469 (66.96)
231 (33.04) | 0.68 | 0.41 | | rs822339 | C
T | 424 (64.29)
236 (35.71) | 420 (60.00)
280 (40.00) | 2.65 | 0.10 | | rs17804441 | A
G | 447(67.71)
213 (32.29) | 486 (69.42)
214 (30.58) | 0.46 | 0.49 | | rs2282055 | C
A | 348 (52.67)
312 (47.33) | 433 (61.88)
267 (38.12) | 11.77 | <0.01 | | rs4143815 | C
G | 468 (70.98)
192 (29.02) | 489 (69.86)
211 (30.14) | 0.20 | 0.65 | | rs2890658 | A
C | 440 (66.67)
220 (33.33) | 430 (61.45)
270 (38.55) | 4.01 | 0.04 | | rs2297137 | G
A | 474 (71.88)
186 (28.12) | 473 (67.54)
227 (32.46) | 3.02 | 0.08 | | rs10125854 | A
G | 406 (61.46)
254 (38.54) | 47 1(67.25)
229 (32.75) | 4.97 | 0.03 | | rs6476976 | C
T | 447 (67.71)
213 (32.29) | 487 (69.57)
213(30.43) | 0.55 | 0.46 | | rs702275 | T
G | 315 (47.77)
345 (52.23) | 383(54.78)
317 (45.22) | 6.68 | 0.01 | | rs16923173 | G
A | 438 (66.37)
222 (33.63) | 449 (64.21)
251 (35.79) | 0.70 | 0.40 | | rs4742095 | G
T | 583 (88.39)
77 (11.61) | 606 (86.52)
94 (13.48) | 1.08 | 0.30 | | PD-1 gene | rs7421861 | T
C | 396 (59.97)
264 (40.03) | 457 (65.22)
243 (34.78) | 4.00 | 0.04 | | rs2227982 | T
C | 371 (56.25)
289 (43.75) | 387 (55.22)
313 (44.78) | 0.15 | 0.70 | | rs10204525 | T
C | 370 (56.10)
290 (43.90) | 431 (61.59)
269 (38.41) | 4.23 | 0.04 |
|
|
Note: PCOS: polycystic ovary syndrome; SNP: single nucleotide polymorphism. . |
