|
| Stressor | Cell of origin | EV cargo contents | Target cell | Reference |
|
| Physical | Gamma ray-irradiated lymphocytes | PI3K/AKT | Lymphocytes | [113] |
| X-ray-irradiated human neuroblastoma SY5Y | AKT pathway | Nonirradiated SH-SY5Y | [164] |
| Heat-shocked MCF-7 & K562 | Unknown | Nonheat-shocked MCF-7 & K562 | [1] |
| Heat-shocked bovine granulosa | miRNAs | Nonheat-shocked bovine granulosa | [121] |
| Heat-shocked bone marrow mesenchymal stem cells | HSP90 and HSP70 | Granulosa cells | [155] |
| Heat-shocked Sca-1(+) stem cells | HSF1, HSP70, and miR-34a | Cardiomyocytes | [154] |
| Heat-treated gastric cancer | Hsp70 and Hsp60 | Dendritic cells & cytotoxic T lymphocytes | [127] |
| Heat-shocked colon adenocarcinoma | HSP70 | Dendritic cells and regulatory T lymphocytes | [128] |
| Lung carcinoma and melanoma | CCL2, CCL3, CCL4, CCL5, and CCL20, HSPs, and tumor antigens | Dendritic cells and cytotoxic T lymphocytes | [132] |
|
| Chemical | Oxidative bovine granulosa | Nrf2 (mRNA and protein) and antioxidant molecules (CAT, PRDX1, and TXN1) | Normal granulosa cells | [136] |
|
| Physiochemical | Heat stress+doxorubicin treated MCF-7 breast cancer | Caspase 3 and caspase 8 | MCF-7 & in vivo (inhibited the growth of implanted breast tumors in mice) | [107] |
|
