Role of Extracellular Vesicles in Compromising Cellular Resilience to Environmental Stressors

Table 3

HSP extracellular vesicles in predictive and prognostic biomarker studies.

HSPs	Disease type	Sample type	Findings	Reference
HSP70	Carcinoma cells	Cell lines	Stimulate migration and cytolytic activity of natural killer cells	[51]
	Breast cancer	Plasma samples	Higher in breast and lung cancers, compared with control groups	[118]
	Lung cancer	Plasma samples	Increase in metastatic lung cancer	[118]
	Human prostate carcinoma	Cell lines	Recognition of the tumor cells by the immune system	[165]
	Breast, lung, and ovarian cancer	Urine samples	HSP70 exosomes were higher in cancer patients than in healthy donors	[166]
HSP90	Oral squamous cell carcinoma	Cell line	Lymph-node-metastatic	[26]
HSP70 and HSP90	Melanoma	Plasma from different disease stages	Disease progression and metastasis	[93]
HSP72	Thymoma, mammary carcinoma, and colon carcinoma	Mouse tumor cell lines	Stat3 activation (tumor survival mechanism and immunosuppressive function)	[87]