Research Article
Association of Polymorphisms of Metabolism-Related Genes with Psoriasis Vulgaris in Han Chinese
Table 3
Comparison of 18 SNPs between PsV cases and controls stratified for HLA-cw06 : 02(+) and HLA-cw06 : 02(-).
| CHR | SNP | Gene | HLA-C06:02(+) | HLA-C06:02(-) | MAF(+) | | | OR | 95% CI | MAF(-) | | | OR | 95% CI | PsV | Con | PsV | Con |
| 2 | rs7593730 | RBMS1 | 0.196 | 0.182 | 0.29 | 0.589 | 1.09 | 0.79- | 1.50 | 0.171 | 0.185 | 0.58 | 0.445 | 0.91 | 0.72- | 1.16 | 3 | rs5186 | AT1R | 0.056 | 0.070 | 0.87 | 0.350 | 0.79 | 0.48- | 1.30 | 0.058 | 0.060 | 0.03 | 0.861 | 0.97 | 0.66- | 1.42 | 5 | rs2303138 | LNPEP | 0.452 | 0.388 | 4.18 | 0.041 | 1.30 | 1.01- | 1.67 | 0.448 | 0.414 | 2.22 | 0.136 | 1.15 | 0.96- | 1.38 | 6 | rs2247056 | HLA | 0.064 | 0.049 | 1.06 | 0.304 | 1.34 | 0.77- | 2.34 | 0.099 | 0.126 | 3.25 | 0.072 | 0.76 | 0.57- | 1.03 | 6 | rs3177928 | HLA | 0.176 | 0.136 | 2.80 | 0.094 | 1.35 | 0.95- | 1.92 | 0.075 | 0.044 | 8.83 | 0.003 | 1.75 | 1.21- | 2.55 | 6 | rs6931514 | CDKAL1 | 0.493 | 0.515 | 0.52 | 0.472 | 0.91 | 0.71- | 1.17 | 0.496 | 0.497 | 0.01 | 0.932 | 0.99 | 0.83- | 1.19 | 6 | rs805303 | HLA | 0.441 | 0.515 | 5.68 | 0.017 | 0.74 | 0.58- | 0.95 | 0.332 | 0.423 | 16.23 | 5.62E-05 | 0.68 | 0.56- | 0.82 | 10 | rs4506565 | TCF7L2 | 0.036 | 0.033 | 0.04 | 0.841 | 1.07 | 0.54- | 2.12 | 0.039 | 0.044 | 0.28 | 0.600 | 0.88 | 0.56- | 1.40 | 10 | rs7901695 | TCF7L2 | 0.036 | 0.030 | 0.22 | 0.641 | 1.18 | 0.58- | 2.40 | 0.039 | 0.043 | 0.15 | 0.698 | 0.91 | 0.57- | 1.45 | 12 | rs11065987 | BRAP | 0.014 | 0.009 | 0.47 | 0.495 | 1.54 | 0.44- | 5.35 | 0.009 | 0.008 | 0.14 | 0.710 | 1.21 | 0.45- | 3.23 | 12 | rs3184504 | SH2B3 | 0.016 | 0.009 | 0.95 | 0.331 | 1.82 | 0.53- | 6.23 | 0.009 | 0.009 | 0.00 | 0.988 | 1.01 | 0.39- | 2.63 | 12 | rs653178 | ATXN2, SH2B3 | 0.017 | 0.009 | 0.98 | 0.323 | 1.84 | 0.54- | 6.29 | 0.009 | 0.008 | 0.04 | 0.851 | 1.10 | 0.42- | 2.90 | 16 | rs255049 | LCAT | 0.147 | 0.146 | 0.01 | 0.939 | 1.01 | 0.72- | 1.44 | 0.144 | 0.140 | 0.07 | 0.798 | 1.03 | 0.80- | 1.34 | 17 | rs4646994 | ACE | 0.259 | 0.266 | 0.05 | 0.816 | 0.97 | 0.72- | 1.30 | 0.271 | 0.269 | 0.01 | 0.914 | 1.01 | 0.82- | 1.26 | 19 | rs1047781 | FUT2 | 0.490 | 0.455 | 1.26 | 0.261 | 1.15 | 0.90- | 1.48 | 0.490 | 0.444 | 3.85 | 0.050 | 1.20 | 1.00- | 1.44 | 19 | rs281379 | FUT2 | 0.031 | 0.036 | 0.23 | 0.634 | 0.85 | 0.44- | 1.66 | 0.027 | 0.014 | 4.50 | 0.034 | 1.95 | 1.04- | 3.67 | 19 | rs492602 | FUT2 | 0.032 | 0.033 | 0.01 | 0.904 | 0.96 | 0.48- | 1.91 | 0.027 | 0.013 | 5.05 | 0.025 | 2.04 | 1.08- | 3.86 | 22 | rs181362 | UBE2L3 | 0.418 | 0.364 | 3.01 | 0.083 | 1.26 | 0.97- | 1.62 | 0.437 | 0.434 | 0.02 | 0.889 | 1.01 | 0.84- | 1.22 |
|
|