Involvement of GABA_A Receptors in the Anxiolytic-Like Effect of Hydroxycitronellal

Table 2

In silico pharmacokinetic data estimated using SwissADME or pkCSM web services.

Compound	^a	^b	TPSA (Å^2)^c	Caco-2 permeability (log Papp; log cm/s)^d	Int. Abs. (%)^e	VDss (log L/kg)^f	Fract. Unb.^g	Total clearance (log mL/min/kg)^h
HC	2.15	-2.04	37.30	1.49	93.84	-0.04	0.50	1.36

^aSwissADME Moriguchi log of octanol-water partition coefficient. ^bSwissADME Ali log of aqueous solubility. ^cSwissADME calculation of Topological Polar Surface Area (TPSA). ^dpkCSM prediction of Caco-2 cell permeability as estimation of absorption in human intestinal mucosa. ^epkCSM prediction of the proportion of compound absorption thought the human small intestine.^fpkCSM prediction of the log of steady state volume of distribution (VDss). ^gpkCSM prediction of compound fraction unbound in plasma (not bound to serum proteins). ^hpkCSM prediction of the log of total drug clearance.