Application of Weighted Gene Coexpression Network Analysis to Identify Key Modules and Hub Genes in Systemic Juvenile Idiopathic Arthritis

Figure 2

Division and validation of coexpression modules. (a) Dendrogram of all genes divided into 17 modules, with dissimilarity based on topological overlap, together with assigned module colors. The number of genes in each module was listed in Supplementary 1 Table S2. (b) The heat map depicts the topological overlap matrix (TOM) among all genes in the analysis. The depth of the red color indicates the correlation between all pair-wise genes. (c) The upper part shows hierarchical clustering of the whole modules. Another is a heat map plot of the adjacencies in the hub gene network. (d) Heat map of the correlation between module eigengenes and the clinical modules.

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