The Potential Genes Mediate the Pathogenicity of Allogeneic CD4⁺T Cell in aGVHD Mouse Model

Table 2

The top 10 up- and downregulated hub genes identified in CD4⁺T cells from each organ.

Group		Hub gene
Allospleen vs. autospleen	Upregulated	Cxcr2, Ccr1, Ccl5, Rgs1, Cxcl10, Cxcr5, Cxcr6, Cxcl2, Cxcl9, and Fpr2
	Downregulated	Ccr7, Cxcl7, Ccr6, Ccr4, Sstr2, Penk, S1pr3, Npy, Hebp1, and Flt3
Alloliver vs. autospleen	Upregulated	Kng1, Plg, Rdh7, Cps1, Serpinc1, Apof, Uox, Fga, Apoc3, and Hpx
	Downregulated	Ccr7, Cxcr4, Ccr3, Ccr4, Htr1b, Ccr6, Cxcl7, S1pr3, Npy, and Ptger3
Allolung vs. autospleen	Upregulated	C3, Cxcl16, Ccl9, Ccr1, Cxcr2, Cxcl5, Cxcl3, Cxcl1, Ccr8, and Cxcl10
	Downregulated	Ccnb1, Cdc20, Aurkb, Aurka, Plk1, Bub1b, Mcm2, Cdc6, Mcm5, and Cdk1