[Retracted] Isovitexin Suppresses Stemness of Lung Cancer Stem-Like Cells through Blockage of MnSOD/CaMKII/AMPK Signaling and Glycolysis Inhibition

Figure 3

The overexpression of MnSOD promoting stemness and glycolysis of LCSLCs. The LCSLCs were infected with recombinant lentivirus packaging MnSOD cDNA (Lent-MnSOD) or GFP (Lent-GFP) or blank control (mock). The overexpression of MnSOD enhanced the sphere-forming rate (a) and colony-forming rate (b) of LCSCs. The overexpression of MnSOD augmented the migratory (c) and invasive (d) capability of LCSLCs. The overexpression of MnSOD increased the expression of CD133, CD44, and ALDH1 (e); Nanog and Bmi1 (f); and MnSOD, p-AMPK, and p-CaMkII in LCSLCs and had no apparent effects on the expression of CaMkII and AMPK (g). (h) The overexpression of MnSOD promoted the glycolysis in LCSLCs. vs. mock or Lent-MnSOD ().

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